Green had previously developed a line of fibroblast cells called 3T3, so he had tools at hand for an experiment. The scientific literature indicated that such “feeder” cells often help other cells proliferate. The colonies were growing on beds of connective tissue cells called fibroblasts. At the time, epithelial cells could not be cultured in laboratories. James Rheinwald, a graduate student, noticed that some mouse teratomas generated colonies of cells resembling epithelial tissue, which lines the surfaces of structures throughout the body. Green was appointed head of the Department of Cellular and Molecular Physiology at HMS in 1980, and served in that role until 1993.Įarly in his career, in the mid-1970s, Green was studying unusual tumors, teratomas, in his lab at MIT. The first large-scale, life-saving use of this procedure was demonstrated with cells grown in Green’s laboratory. Green was credited with developing the first therapeutic application of cultured cells, using keratinocytes for the regeneration of epidermis on severely burned patients. 31 at the age of 90 after having served HMS for 35 years.
#Green stem skin
Howard Green, the George Higginson Professor of Cell Biology Emeritus at Harvard Medical School, a pioneer in the science of skin regeneration, died on Oct. Harvard COVID-19 Information: Keep Harvard Healthy.Celebrating 50 Years of Diversity and Inclusion.Research Departments, Centers, Initiatives and more.
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